Cystatic - C and relation to bio-inflammatory markers

Kidney International (2007) 71, 239–244. doi:10.1038/sj.ki.5002042; published online 20 December 2006

Kidney function and markers of inflammation in elderly persons without chronic kidney disease: The health, aging, and body composition study

C R Keller^1,2, M C Odden², L F Fried³, A B Newman⁴, S Angleman⁵, C A Green⁶, S R Cummings^1,7, T B Harris⁵ and M G Shlipak^1,2,8

Abstract

Inflammatory markers are elevated in persons with estimated glomerular filtration rates less than 60 ml/min/1.73 m². As cystatin C may detect small changes in kidney function not detected by estimated glomerular filtration rate, we evaluated the association between cystatin C and serum markers of inflammation in older adults with estimated glomerular filtration rate 60. This is an analysis using measures from the Health, Aging, and Body Composition Study, a cohort of well-functioning adults aged 70–79 years.

Cystatin C correlated with all five inflammatory biomarkers: C-reactive protein (r=0.08), interleukin-6 (r=0.19), tumor necrosis factor (TNF-) (r=0.41), soluble TNF receptor 1 (STNF-R1) (r=0.61), and soluble TNF receptor 2 (STNF-R2) (r=0.54); P<0.0005>

Participants with a cystatin C1.0 mg/l had significantly higher levels of all five biomarkers compared to those with a cystatin C<1.0>P<0.05).>

Cystatin C has a linear association with inflammatory biomarkers in an ambulatory elderly cohort with estimated glomerular filtration rates 60; associations are particularly strong with TNF- and the STNF-R.